Table 2.

List of clinical trials with Olive Oil Polyphenols.

Health Status	N.1	Study	Treatment	Efficacy	Ref.
Hypercolesterolemia	4	Randomized, double-blind, placebo and active comparator (Armolipid Plus) controlled study	Food supplement called Body Lipid, containing monacolin K (10 mg), berberine (500 mg), coenzyme Q10 (2 mg) and HT (5 mg)	+	[60]
		Randomized, controlled, double-blind, crossover human trial	VOO containing polyphenols 80 mg/kg, or 500 mg/kg, or a mixture from VOO and thyme (500 mg/kg, 1:1)	+	[61]
		Randomized, double-blind crossover, controlled trial	olive oils with different phenolic contents, 80 or 400 ppm	+	[62]
		Observational non-randomized study	Cholesfytol (10 mg Monacolin K and 5 mg HT)	+	[63]
Obesity	1	Randomized, double-blinded, placebo-controlled, crossover	51.1 mg oleuropein, 9.7 mg hydroxytyrosol	+/−	[64]
Metabolic syndrome	2	Randomized double-blind placebo-controlled trial	Cholesfytolplus capsule (10.82 mg Monacolins and 9.32 mg HT)	+	[65]
		Randomized double blind placebo controlled randomized trial	Cholesfytolplus capsule (10.82 mg Monacolins and 9.32 mg HT)	+	[66]
Hypertension	2	Randomized, double-blind, controlled, crossover trial	Phenolic-rich olive leaf extract (136.2 mg Ole and 6.4 mg HT per day)	+	[47]
		Randomized, double blind, crossover trial	Virgin OO enriched with polyphenols-961 mg/kg	+	[45]
Arterial stiffness	1	Randomized double-blind placebo-controlled trial	Standardized olive fruit extract 250 mg (50 mg HT) or 500 mg (100 mg HT)	+	[67]
Healthy volunteers	9	Randomized double-blinded, placebo-controlled crossover trial	15 mg/day of HT	+	[68]
		Randomized, cross-over, placebo-controlled and double-blind trial group.	25 mg/day HT (extract of olive mill wastewater called Hytolive)	+	[69]
		Randomized, double-blind, placebo-controlled, cross-over trial	51 mg Ole and 10 mg HT	+	[70]
		Randomized double-blind, placebo-controlled study	5 and 25 mg/d HT	−	[44]
		Randomized double-blind placebo-controlled study	Virgin OO enriched with polyphenols—5358 mg/L	+	[71]
		Randomized, double-blind crossover, controlled trial	OO with a low polyphenol content (2.7 mg/kg) or a high phenolic content (366 mg/kg)	+	[72]
		Randomized, double-blind crossover, controlled trial	OO with low (2.7 mg/kg of olive oil), medium (164 mg/kg), or high (366 mg/kg) phenolic content	+	[73]
		Randomized, double-blind crossover, controlled trial	OO with low (2.7 mg/kg), medium (164 mg/kg), or high (366 mg/kg) phenolic content	+	[74]
		Randomized, double-blind crossover, controlled trial	OO with low (0 mg/kg), medium (68 mg/kg) or high (150 mg/kg) phenolic content	+	[75]

Abbreviations: + = cardioprotective effect(s); +/− = partial cardioprotective effect(s); − = loss of cardioprotective effect(s). ¹ Number of clinical trials examined