Figure 9.
Proposed mechanism of coelonin inhibiting LPS-stimulated activation of NF-κB and inducing G1 phase cell-cycle arrest in RAW264.7 cells. Coelonin inhibits the expression of inflammatory cytokines IL-1β, IL-6 and TNF-α in RAW264.7 cells treated by LPS may partially through the PTEN/AKT pathway. However, it induces G1 cell cycle arrest of RAW264.7 cells by inhibiting the degradation of p27Kip1 in a PTEN-dependent manner. The black arrow section has been verified, while the red arrow section needs further validation. The question mark indicated that coelonin may inactivate NF-κB by inhibiting TLR4/MyD88/TRAF6/TAK1 signal pathway, the canonical pathway of NF-κB activation.