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. 2019 Sep 11;20(18):4482. doi: 10.3390/ijms20184482

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of MCM4 silencing on cell proliferation, migration, and invasion in LUAD cells. (A,B) The effects of siMCM4 in LUAD cells. MCM4 mRNA and protein expression levels were significantly reduced by siMCM4 transfection into A549 and H1299 cells (72 h after transfection). Expression of GAPDH/GAPDH was used as an internal control. (C) Cell proliferation activities were blocked by siMCM4 transfection into LUAD cells. (D,E) Cell migration and invasive abilities were blocked by siMCM4 transfection into LUAD cells (* p < 0.001).