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. 2019 Sep 4;20(18):4330. doi: 10.3390/ijms20184330

Figure 6.

Figure 6

Schema of the present study. PCA based on mRNA levels analyzed by RNA sequencing was conducted in CCC and HGSC groups. The top three most highly expressed genes were chosen from the genes contributing to the first principal component of PCA in CCC and HGSC. Knockdown experiments for the selected genes showed that CPNE8 and BHLHE41 promoted the proliferation of CCC- and HGSC-derived cells, respectively. Functional enrichment and pathway analyses also showed that these two genes were related to cancer cell growth signaling.