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. 2019 Sep 3;11(9):1298. doi: 10.3390/cancers11091298

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Significantly regulated Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways between the proteomes of (A) papillary renal cell carcinoma (pRCC) type I and healthy kidneys and (B) of the transcriptome data retrieved from The Cancer Genome Atlas (TCGA). Shown is a collapsed list, the applied cutoff is p ≤ 0.05 and q ≤ 0.1. Specific enrichment plots for the KEGG pathway “oxidative phosphorylation” are shown for (C) the proteome and (D) the transcript data from TCGA. The Vacuolar-type H ± ATPases (V-ATPases) were removed from the pathway “oxidative phosphorylation” displayed in C and D, as they are wrongly assigned in this KEGG pathway. Normalized enrichment score, NES; Size, number of proteins/genes identified within a pathway.