Figure 3.
P1G10 inhibits erythema induced by UVB. Mice were exposed to a single UVB dose (2.4 J cm−1) followed by topical application of P1G10. (A) Erythema intensity of basal, control, Natrosol gel vehicle, 0.1% and 1.0% P1G10 dispersed in Natrosol. Skin biopsies were fixed and stored in 10% buffered formalin and processed for histological and morphometric analysis. (B) Epidermal thick analysis of: Basal, control, vehicle, 0.1% and 1.0% P1G10 24 h after irradiation. For details see Materials and Methods. The data represent total skin thickness (10×objective): mean ± SEM of 6–8 animals per group (** p < 0.01 and * p < 0.05 difference versus vehicle, ANOVA, Newman–Keuls post-test).