Figure 7.
Effects of endogenous 5-HT2A- and, D2-receptors on RIS-induced hypothermia. Hypothermia was defined as a reduction of at least 2 °C below baseline (normothermia). NBOH-2C-CN hydrochloride does not alter body temperature, but bromocriptine mesylate significant decreased body temperature at 80 min after the administration, and (±)-DOI hydrochloride slightly increases body temperature at 60 min after the administration. Namely, RIS-induced hypothermia is interrupted following the administration of NBOH-2C-CN hydrochloride and (±)-DOI hydrochloride. The bars indicate the means ± SEM, n = 7/group, two-way analysis of variance (ANOVA) with a post-hoc Bonferroni’s multiple comparison test (* p < 0.05 vs. sham group; # p < 0.05 vs. RIS group).