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. 2019 Sep 1;8(9):346. doi: 10.3390/antiox8090346

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of a 24-h treatment with either resveratrol alone (5 µM) or resveratrol + EX527 (5 µM and 13.4 µM, respectively) combination on TBARS levels (a), glutathione redox balance (b), and arg-pyrimidine concentration (c) in high glucose-challenged HUVECs. Representative blots are also shown (c). Data are expressed as means and S.E.M. Abbreviations: CTR—vehicle; HG—high glucose; HG + RSV—high glucose + resveratrol; HG + RSV + EX527—high glucose + resveratrol + EX527; GSH—reduced glutathione; GSSG—glutathione disulfide; TBARS—thiobarbituric acid-reactive substances. Means sharing the same letter are not significantly different from each other (one-way ANOVA and Tukey’s multiple comparisons test): Panel (a): a vs. b, p < 0.05; b vs. c, p < 0.05; a vs. c, p < 0.001 (N = 4). Panel (b): a vs. b, p < 0.001; b vs. c, p < 0.001; a vs. c, p < 0.05 (N = 8). Panel (c): a vs. b, p < 0.05 (N = 4).