Table 1.
Overview of the hematologic parameters in WT, LDLR+/–, LDLR–/–, and ABCA1–/– hamsters before IS procedure.
| RBC (1012/L) |
WBC (109/L) |
HGB (g/L) | HCT (%) | MCV (fl) | MCH (pg) | MCHC (g/L) |
PLT (109/L) |
MPV (fl) | PDW | LYM | LYM% | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | 6.3 ± 0.7 | 10.9 ± 1.6 | 145.6 ± 21.6 | 43.15 ± 2.1 | 60.95 ± 3.1 | 20.9 ± 1.6 | 359 ± 44.6 | 343 ± 129 | 4.8 ± 1.7 | 20.9 ± 0.5 | 2.9 ± 0.8 | 36.9 ± 4.1 |
| LDLR+/– | 7.1 ± 0.4 | 9.7 ± 1.1 | 140.8 ± 6.7 | 41.3 ± 1.6 | 61.8 ± 2.4 | 19.9 ± 2.1 | 326.3 ± 39 | 456.7 ± 32.5 | 3.4 ± 0.3 | 17.6 ± 0.6 | 5.5 ± 1.7 | 33.5 ± 2.8 |
| LDLR–/– | 8.3 ± 0.7 * | 11.9 ± 1.57 | 153.7 ± 17.4 | 41.1 ± 1.5 | 59.9 ± 2.9 | 21.5 ± 1.8 | 344.8 ± 15.5 | 432.2 ± 18.7 | 3.4 ± 0.3 | 17.6 ± 0.5 | 6.3 ± 1.8 * | 52.7 ± 2.5 * |
| ABCA1–/– | 7.8 ± 0.3 | 22.8 ± 2.4 ** | 167.3 ± 3.7 | 42.4 ± 0.9 | 55.9 ± 3.4 | 20.3 ± 1.0 | 413 ± 20.3 | 239.8 ± 33.7 ** | 1.53 ± 0.3 ** | 14.3 ± 0.3 ** | 6.1 ± 1.9* | 51.8 ± 1.9 ** |
Data are expressed as mean ± SD. * p < 0.05; ** p < 0.01 versus WT. n = 8 per genotype.