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Plots of the distance and angle distributions defining the positioning of the globular domain with respect to the membrane in CG and AA MD simulations of CYP 2C9 (A) and CYP 2C19 (B). The globular domain of CYP 2C9 tended to be more immersed in the membrane than CYP 2C19 and the two adopted distinct orientations: class A (angle β < 125°) for CYP 2C9, and class B (angle β > 130°) for CYP 2C19.
