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. 2019 Aug 27;8(9):981. doi: 10.3390/cells8090981

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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AC9 deletion impairs isoproterenol-induced regulation of I_Ks. I_Ks currents in ventricular myocytes of IKs (A) and IKs-AC9KO (B) mice in before (control, left panels) and after perfusion of 1 µM isoproterenol and 1 µM okadaic acid (ISO, right panels). Currents were elicited by applying depolarizing potentials to various levels ranging from −80 to +80 mV for 2 s from a holding potential of −40 mV. I-V relationships for tail current in IKs (C) and IKs-AC9KO (D) before (control) and after 1 µM isoproterenol and 1 µM okadaic acid (ISO). (E) Shift of V₅₀ induced by 1 µM isoproterenol and 1 µM okadaic acid perfusion of myocytes from IKs and IKs-AC9KO mice. Statistics: t-test, * p <0.05, (Mann-Whitney), number of cells is indicated on the figure for each condition.