Figure 4.

The iPS cell transplantation model and application for iPS cell transplantation study using MHC defined cynomolgus macaques. (A) This monkey model is used for analyses of engraftment rate of transplanted cells and inflammatory responses and used for evaluating safety and usefulness of iPS cell transplantation. (B) Summary of transplantation outcome between MHC matched recipient and mismatched recipient. MHC type mismatch in transplantation causes severe rejection. This transplantation model can be applied to the development of a therapy for suppressing graft rejection and an efficient protocol of an immunosuppressant.