Table 4.

Top fifteen pathways with the largest weights fitted by PKB. In each column, pathways are sorted in descending order from top to bottom. Pathways in the first two columns are from GO Biological Process pathways and the third column from Biocarta.

	Metabric (Grade)	Glioma (Grade)	Melanoma (Met)
1	Cell aggregation	Homophilic cell adhesion via plasma membrane adhesion molecules	Lectin induced complement pathway
2	Sequestering of metal ion	Neuropeptide signaling pathway	Classical complement pathway
3	Glutathione derivative metabolic process	Multicellular organismal macromolecule metabolic process	Phospholipase c delta in phospholipid associated cell signaling
4	Antigen processing and presentation of exogenous peptide antigen via mhc class i	Peripheral nervous system neuron differentiation	Fc epsilon receptor i signaling in mast cells
5	Sterol biosynthetic process	Positive regulation of hair cycle	Inhibition of matrix metalloproteinases
6	Pyrimidine containing compound salvage	Peptide hormone processing	Regulation of map kinase pathways through dual specificity phosphatases
7	Protein dephosphorylation	Hyaluronan metabolic process	Estrogen responsive protein efp controls cell cycle and breast tumors growth
8	Homophilic cell adhesion via plasma membrane adhesion molecules	Positive regulation of synapse maturation	Chaperones modulate interferon signaling pathway
9	Cyclooxygenase pathway	Stabilization of membrane potential	Il-10 anti-inflammatory signaling pathway
10	Establishment of protein localization to endoplasmic reticulum	Lymphocyte chemotaxis	Reversal of insulin resistance by leptin
11	Negative regulation of dephosphorylation	Insulin secretion	Bone remodeling
12	Xenophagy	Positive regulation of osteoblast proliferation	Cycling of ran in nucleocytoplasmic transport
13	Attachment of spindle microtubules to kinetochore	Negative regulation of dephosphorylation	Alternative complement pathway
14	Fatty acyl coa metabolic process	Trophoblast giant cell differentiation	Cell cycle: g${}^2$/m checkpoint
15	Apical junction assembly	Synaptonemal complex organization	Hop pathway in cardiac development