Figure 6.

The molecular biomarkers and their correlation with the corresponding imaging features. (a) The normalized expression levels of the four molecular (“genomic”) biomarkers in tumor stages T2c and T3b. (b) Principal Component analysis (PCA) clustering of tumor samples T2c and T3b based on the normalized expression levels of the four biomarkers. (c) Screenshots from the Osirix software [46] for fusion of MRI delineated prostate regions of interests. We outline the prostate volume in coronal axis T2-weighted fast MRI images for both T2c and T3b samples. (d) The correlation matrix between the normalized expression levels of the four biomarkers and the extracted aggressiveness-related radiographic features C2 and C3. The significant correlations (FDR < 0.05) are marked with (*). C2 category represents the histogram of tumor volume intensity and basic statistical metrics such as mean, median, standard deviation, and kurtosis. The C3 feature category denotes the texture analysis of the tumor volume and includes Gray-Level Co-occurrence Matrix (GLCM) features such as contrast, energy, and homogeneity metrics [3]. The original data for Figure 6 was shown in Supplementary Materials.