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. 2019 Sep 17;20(18):4599. doi: 10.3390/ijms20184599

Figure 2.

Figure 2

PTX3 overexpression reduces angiogenesis. CD31 immunohistochemistry and morphometric analysis in mock (A) and PTX3 (B) transfected MC17-51 tumor grafts growing s.c. in syngeneic C57BL/6 mice and in wild type MC17-51 tumor grafts growing s.c. in WT C57BL/6 (D) and transgenic TgN(Tie2-hPTX3) mice (E) mice. Morphometric analysis shows a significant decrease of CD31 positive vessels (arrows) following PTX3 overexpression by tumor cells (C) or by transgenic tumor stroma (F) when compared to their corresponding controls (A,D, respectively). * p < 0.05. Scale bar: A,B,D,E 60 µm.