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. 2019 Sep 3;8(9):1024. doi: 10.3390/cells8091024

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of chronic demyelination on the neuro-axonal/-dendritic compartment. (A) Numbers and (B) densities of neurons in the cerebral cortex (CTX) and the subcortical area (SCTX) of control (Co) (n = 6) and 12 weeks of cuprizone-intoxicated (Cup) mice (n = 6) analyzed with design-based stereology. (C) Neuropil volumes and volumes occupied by nerve cell perikarya in the SCTX of Co (n = 6) and 12-week Cup mice (n = 6). (D) Quantification of amyloid precursor protein (APP)-positive spheroids in the thalamus (TH) and internal capsule (IC) of chronically demyelinated mice (n = 5). Data are shown as individual values and means per group (lines). Statistical analysis revealed significant differences between Co and Cup in (D) (TH, p = 0.02; IC, p = 0.02); *p < 0.05.