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MPA: Mechanism of Action. IMPDH catalyzes the rate-limiting, NAD-dependent oxidation of inosine monophosphate (IMP) to xanthosine 5′-monophosphate (XMP), which is an intermediate metabolite in the production of guanosine-triphosphate (GTP). MPA is a potent, selective, reversible, and noncompetitive inhibitor of IMPDH. Abbreviations: SAMP: succinyl-AMP, and PRPP: phosphoribosyl pyrophosphate.
