Table 5.

Top 10 molecular function GO terms from Webgestalt analysis ¹.

	Gene Set	Description	# of Genes in Pathway	DEG in Pathway	Enrichment Score	p-Value
SE−DEGs	GO:1990841	promoter-specific chromatin binding	46	2	26.787	2.48 × 10−3
	GO:0019199	transmembrane receptor protein kinase activity	81	2	15.212	7.51 × 10−3
	GO:0019838	growth factor binding	138	2	8.929	2.07 × 10−2
	GO:0001653	peptide receptor activity	149	2	8.270	2.39 × 10−2
	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	444	3	4.163	3.36 × 10−2
	GO:0008237	metallopeptidase activity	185	2	6.661	3.57 × 10−2
	GO:1901567	fatty acid derivative binding	27	1	22.819	4.30 × 10−2
	GO:0017171	serine hydrolase activity	208	2	5.924	4.41 × 10−2
	GO:0043177	organic acid binding	212	2	5.812	4.57 × 10−2
	GO:0035035	histone acetyltransferase binding	29	1	21.245	4.61 × 10−2
SE−Drug DEGs	GO:0140098	catalytic activity, acting on RNA	350	3	3.912	4.02 × 10−2
	GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	28	1	16.299	5.96 × 10−2
	GO:0060090	molecular adaptor activity	194	2	4.705	6.69 × 10−2
	GO:0050839	cell adhesion molecule binding	478	3	2.864	8.53 × 10−2
	GO:1990841	promoter-specific chromatin binding	46	1	9.921	9.61 × 10−2
	GO:0097110	scaffold protein binding	58	1	7.868	1.20 × 10−1
	GO:0000049	tRNA binding	59	1	7.735	1.22 × 10−1
	GO:0070491	repressing transcription factor binding	73	1	6.252	1.48 × 10−1
	GO:0015631	tubulin binding	321	2	2.843	1.55 × 10−1
SE−HIV DEGs	GO:0019865	immunoglobulin binding	23	3	16.235	7.93 × 10−4
	GO:0001228	DNA−binding transcription activator activity, RNA polymerase II−specific	444	11	3.084	8.52 × 10−4
	GO:0016209	antioxidant activity	84	4	5.927	4.63 × 10−3
	GO:0070888	E-box binding	50	3	7.468	7.50 × 10−3
	GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	55	3	6.789	9.76 × 10−3
	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II−specific	267	6	2.797	2.05 × 10−2
	GO:0060589	nucleoside-triphosphatase regulator activity	348	7	2.504	2.19 × 10−2
	GO:0005496	steroid binding	92	3	4.059	3.78 × 10−2
	GO:0015026	coreceptor activity	43	2	5.789	4.66 × 10−2

¹ Parameters for the enrichment analysis were as follows: Enrichment method: ORA, organism: hsapiens, enrichment categories: geneontology_Molecular_Function_noRedundant, minimum number of IDs in the category: 5, maximum number of IDs in the category: 2000, FDR method: Benjamini and Hochberg, significance level: Top 10.