Skip to main content
. 2019 Sep 3;8(9):1027. doi: 10.3390/cells8091027

Table 7.

Top 10 KEGG pathways from Webgestalt analysis 1.

Gene Set Description # of Genes in Pathway DEG in Pathway Enrichment Score p-Value
SE−DEGs hsa04657 IL-17 signaling pathway 93 4 17.374 6.69 × 10−5
hsa05150 Staphylococcus aureus infection 56 3 21.640 3.25 × 10−4
hsa05323 Rheumatoid arthritis 90 3 13.465 1.31 × 10−3
hsa04928 Parathyroid hormone synthesis, secretion and action 106 3 11.432 2.10 × 10−3
hsa04080 Neuroactive ligand-receptor interaction 277 4 5.833 4.13 × 10−3
hsa05031 Amphetamine addiction 68 2 11.881 1.20 × 10−2
hsa04917 Prolactin signaling pathway 70 2 11.541 1.27 × 10−2
hsa04610 Complement and coagulation cascades 79 2 10.226 1.59 × 10−2
hsa05132 Salmonella infection 86 2 9.394 1.87 × 10−2
hsa05142 Chagas disease (American trypanosomiasis) 102 2 7.920 2.58 × 10−2
SE−Drug DEGs hsa04914 Progesterone−mediated oocyte maturation 99 2 9.181 1.95 × 10−2
hsa04931 Insulin resistance 107 2 8.494 2.25 × 10−2
hsa04114 Oocyte meiosis 124 2 7.330 2.96 × 10−2
hsa03040 Spliceosome 133 2 6.834 3.37 × 10−2
hsa04910 Insulin signaling pathway 137 2 6.634 3.56 × 10−2
hsa04150 mTOR signaling pathway 151 2 6.019 4.25 × 10−2
hsa01523 Antifolate resistance 31 1 14.659 6.61 × 10−2
hsa00260 Glycine, serine and threonine metabolism 40 1 11.361 8.46 × 10−2
hsa00970 Aminoacyl-tRNA biosynthesis 44 1 10.328 9.26 × 10−2
SE−HIV DEGs hsa05150 Staphylococcus aureus infection 56 5 9.836 1.41 × 10−4
hsa04380 Osteoclast differentiation 128 5 4.303 5.93 × 10−3
hsa05202 Transcriptional misregulation in cancer 186 6 3.554 6.58 × 10−3
hsa05322 Systemic lupus erythematosus 133 5 4.142 6.95 × 10−3
hsa00515 Mannose type O-glycan biosynthesis 23 2 9.580 1.82 × 10−2
hsa04115 p53 signaling pathway 72 3 4.590 2.73 × 10−2
hsa05166 Human T-cell leukemia virus 1 infection 255 6 2.592 2.75 × 10−2
hsa00410 Beta-Alanine metabolism 31 2 7.108 3.19 × 10−2
hsa04710 Circadian rhythm 31 2 7.108 3.19 × 10−2

1 Parameters for the enrichment analysis were as follows: Enrichment method: ORA, organism: hsapiens, enrichment categories: pathway_KEGG, minimum number of IDs in the category: 5, maximum number of IDs in the category: 2000, FDR method: Benjamini and Hochberg, significance level: Top 10.