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. 2019 Sep 12;11(9):1349. doi: 10.3390/cancers11091349

Figure 5.

Figure 5

Nuclear MDM4 signal is increased in chemo-resistant high-grade serous ovarian cancer (HGSOC). (A) Representative pictures of MDM4 showing nuclear/cytoplasmic (upper panel) and only nuclear (lower panel) signal in HGSOC, irrespective of their IRS score. Right panels represent magnification of left panels (Scale bar, 100 µm). (B) MDM4 levels (mean ± SD, IHC = immunoreactive score) in nuclear and nuclear/cytoplasmic compartments of sensitive and resistant patients (** p < 0.01, two-tailed unpaired t-test, n = 33, DF = 31, t = 2.773, ** p = 0.0093). (C), qPCR of STS mRNA extracted from available matched frozen samples examined in B (mean ± SD, two-tailed unpaired t-test, n = 11, DF = 9, t = 3.34, ** p = 0.0087).