Figure 6.

Nuclear MDM4 correlates with decreased cell death and DFS in HGSOC. (A) Representative pictures of cleaved caspase-3 staining (CC3) in HGSOC (left and right panels show high and low expression levels, respectively, scale bar 100 µm). (B) CC3 expression in sensitive and resistant patients (mean ± SD, two-tailed unpaired t-test, n = 31, DF = 29, t = 2.230, * p = 0.034). (C), Correlation between CC3 and nuclear MDM4 in HGSOC (Spearman rank correlation, p < 0.0001, r = 0.7, 95% CI −0.8 to 0.4). (D,E) Disease-free survival (D) and overall survival (E) of patients according to the expression of nuclear MDM4 in HGSOC. High expression of MDM4 in the nuclear compartment is associated with decreased disease-free survival and overall survival (Log-rank test (D) χ²= 4.172, df = 1 p = 0.041; (E) χ²= 3.670, df = 1 p = 0.055).