Figure 5.

Correlation between IL-1β release in response to inflammasome agonists and sulfasalazine (SSZ) in term of the CD4+ T cells count or viral load. The effect of SSZ on IL-1β release through inflammasomes was determined in people living with HIV, on the basis of the CD4+ T cell count (A,B) and viral load (C,D). The correlations were estimated using Spearman’s rank correlation coefficients. The r and p values of the correlations are indicated at the top of each figure; a p-value of <0.05 was considered statistically significant. Black spots represent PBMCs treated only with inflammasome agonists. White spots represent PBMCs treated with inflammasome agonists and SSZ. Dashed-line indicates the correlation trend in the presence of SSZ. Continuous line indicates the correlation trend in the absence of SSZ.