Table 2.
Top 25 biological processes related to the downregulated proteins. The first column represents the biological process. The second column is the number of downregulated proteins through increased miR195/497 expression in RKO or HCT116 cells in the dataset related to that process. In bold the processes involved in mitosis. FDR: False Discovery Rate.
| Gene Ontology Term | #Proteins | FDR |
|---|---|---|
| cell-cycle | 46 | 7.06 × 10−14 |
| cell division | 30 | 7.06 × 10−14 |
| mitotic cell-cycle | 32 | 6.12 × 10−13 |
| mitotic cell-cycle process | 30 | 1.42 × 10−12 |
| cell-cycle process | 36 | 4.10 × 10−12 |
| mitotic nuclear division | 16 | 8.82 × 10−11 |
| nuclear division | 19 | 1.65 × 10−09 |
| sister chromatid segregation | 14 | 3.43 × 10−09 |
| cellular component organization or biogenesis | 86 | 5.85 × 10−09 |
| organelle organization | 61 | 1.99 × 10−08 |
| chromosome organization | 32 | 2.56 × 10−08 |
| mitotic sister chromatid segregation | 12 | 4.31 × 10−08 |
| mitotic spindle organization | 10 | 2.72 × 10−07 |
| microtubule cytoskeleton organization involved in mitosis | 11 | 2.72 × 10−07 |
| cytoskeleton organization | 29 | 5.12 × 10−07 |
| mitotic spindle assembly | 8 | 9.57 × 10−07 |
| cellular component biogenesis | 50 | 1.13 × 10−06 |
| cellular component organization | 78 | 1.29 × 10−06 |
| cell-cycle phase transition | 15 | 1.85 × 10−06 |
| spindle organization | 11 | 2.32 × 10−06 |
| spindle assembly | 9 | 2.62 × 10−06 |
| regulation of cell-cycle | 30 | 3.57 × 10−06 |
| cellular process | 151 | 5.64 × 10−06 |
| mitotic cell-cycle phase transition | 14 | 6.70 × 10−06 |
| regulation of cell-cycle process | 22 | 1.20 × 10−05 |