Table 3.
Isolated papillary muscle at baseline condition (2.5 mM Ca2+).
| Variables | Groups | Effect | |||||
|---|---|---|---|---|---|---|---|
| Control | Control + Ly | HSF | HSF + Ly | Diet | Ly | Interaction | |
| DT(g/mm2) | 5.96 ± 1.25 | 6.29 ± 1.65 | 4.41 ± 1.11 * | 6.05 ± 1.19 # | 0.066 | 0.046 | 0.173 |
| RT(g/mm2) | 0.65 ± 0.11 | 0.61 ± 0.11 | 0.63 ± 0.08 | 0.57 ± 0.11 | 0.512 | 0.202 | 0.844 |
| +dT/dt(g/mm2/s) | 61.9 ± 10.1 | 63.5 ± 18.4 | 60.8 ± 11.7 | 65.5 ± 19.7 | 0.934 | 0.573 | 0.773 |
| −dT/dt(g/mm2/s) | 16.8 ± 2.4 | 17.5 ± 2.9 | 15.5 ± 3.3 | 16.1 ± 2.9 | 0.193 | 0.569 | 0.933 |
| CSA(mm2) | 1.11 ± 0.12 | 1.10 ± 0.23 | 1.25 ± 0.27 | 1.17 ± 0.3 | 0.181 | 0.801 | 0.912 |
Data are expressed in mean ± standard deviation (n = 6 animals/group). Comparison by Two-way ANOVA with Tukey post-hoc (p < 0.05): * HSF vs Control; # HSF vs HSF+Ly. DT, Maximum developed tension normalized per cross-sectional area of the papillary muscle; RT, Resting tension normalized per cross-sectional area of the papillary muscle; peak of the positive, +dT/dt and negative, −dT/dt tension derivatives normalized per cross-sectional area of the papillary muscle; CSA, cross-sectional area.