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. 2019 Sep 4;11(9):1306. doi: 10.3390/cancers11091306

Figure 1.

Figure 1

SERPINA1 expression is downregulated in NSCLC and is a prognostic factor for overall and disease-free survival. (A) Relative expression (ΔCt) of SERPINA1 in tumor and in paired non-tumor lung tissues. SERPINA1 expression was normalized to reference genes ESD and RPS18. A higher relative value means a lower gene expression. (B) SERPINA1 expression ratio (tumor vs. non-tumor lung tissue) in 351 NSCLC patients. Dotted line indicates equal expression in tumor and lung tissue. (C–F). Kaplan-Meier overall and disease-free survival curves for all patients. (G) and (H) Kaplan-Meier overall and disease-free survival curves for current smokers. The program cut-off finder (http://molpath.charite.de/cutoff/) was used to define the values separating the groups. p < 0.05 was considered significant.