Table 1.
Characteristics of included randomized controlled trials (RCTs).
| Study ID | Outcomes | Description of Participants | Study Duration | Intervention | Placebo | Lifestyle Adjustments | Funding |
|---|---|---|---|---|---|---|---|
| Barriocanal 2008 a [ 15 ] | BMI, SBP, DBP, FBG, TC, HDL-C, LDL-C, TAG, HbA1c | Men and women with or without T1D or T2D (n = 86) | 3 months | Stevioside 750 mg/day Purity: ≥92% |
Matching placebo (content not specified) | Continuation of antihypertensive and antidiabetic medication during intervention | Not specified |
| Chan 2000 [ 16 ] | BMI, SBP, DBP, FBG, TC, HDL-C, TAG | Mild to moderate hypertensive men and women (n = 100) | 1 year | Stevioside 750 mg/day Purity: Not available |
Matching placebo (content not specified) | Prohibition of antihypertensive medication. Dietary counselling | Not specified |
| da Silva 2006 [ 17 ] | BMI, FBG, TC, HDL-C, LDL-C, TAG | Untreated hyperlipidemic men and women (n = 43) | 90 days | Stevioside 200 mg/day Purity: Not available |
Talcum | Normal lifestyle | Public institutions |
| Ferri 2006 [ 60 ] | BMI, SBP, DBP, FBG, TC, HDL-C, LDL-C, TAG, HbA1c | Untreated mild-hypertensive men and women (n = 14) | 24 weeks | Stevioside: 7 weeks: 3.75 mg/kg/day 11 weeks: 7.0 mg/kg/day 6 weeks: 15.0 mg/kg/day Purity: Not available |
Talcum | Normal lifestyle | Government |
| Gregersen 2004 b [ 18 ] | SBP, DBP | Overweight and obese men and women with T2D (n = 12) | 4 h | Stevioside 1000 mg Purity: 91% |
Maize starch | Prohibition of oral antidiabetic medication prior to intervention | Public institutions |
| Hsieh 2003 [ 19 ] | BMI, SBP, DBP, FBG, TC, HDL-C, TAG | Mild-hypertensive men and women (n = 168) | 2 years | Stevioside 1500 mg/day Purity: Not available |
Matching placebo (content not specified) | Continuation of antihypertensive medication during intervention | Not specified |
| Jeppesen 2006 [ 43 ] | SBP, DBP, FBG, TC, HDL-C, TAG, HbA1c | T2D men and women (n = 37) | 3 months | Stevioside 1500 mg/day Purity: Not available |
Maize starch | Prohibition of antidiabetic medication two weeks prior to intervention | Not specified |
BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; FBG: fasting blood glucose; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; TAG: triglyceride; HbA1c: glycated hemoglobin; T1D: type 1 diabetes; T2D: type 2 diabetes. a Three RCTs in one study. Group 1: T1D; Group 2: T2D; Group 3: Healthy. b Cross-over trial.