Skip to main content
. 2019 Sep 8;8(9):1053. doi: 10.3390/cells8091053

Figure 2.

Figure 2

Melatonin reduced endoplasmic reticulum stress and lipogenesis in wild type (WT) mice, not in SIRT1 heterozygous (HET) mice on a high-fat diet. (A) Representative pictures of GRP78 protein staining in the liver. (B) Densitometric analysis of GRP78 staining. (C) GRP78 Western blotting and relative quantification. (D) SREBP1 protein staining in WT and HET mice fed with a maintenance (STD) or high-fat diet. (HFD) with or without melatonin intake. (E) Densitometric analysis of SREBP1 staining. Values are mean ± SEM. Scale bars represent 10 µm. P: portal space; V: central vein. Dark circle: SREBP1-positive nuclei. * p < 0.05 vs. WT STD, § p < 0.05 vs. HET STD, ** p < 0.05 vs. WT HFD.