Table 3.
Top regulatory networks identified by IPA. Genes detected in the TCGA-OV27 cohort are shown in bold.
| Top Diseases and Functions | Molecules in Network | Score | Focus Molecules |
|---|---|---|---|
| Dermatological diseases and conditions, Organismal injury and abnormalities, immunological disease | ACTA2, ADM, APLNR, Akt, CCKBR, CD6, ERK, ERK1/2, FAS, GLI2, HCAR2, IFIT1, IFIT3, IL1RN, ILK, Interferon alpha, Jnk, MAPK8IP1, Mek, NFkB (complex), OAS1, OAS2, OAS3, P38 MAPK, PI3K (family), PPP1CC, Raf, SH2B3, SLC15A3, SLC43A3, TCR, TRIM22, UBE2L6, UNG, WEE1 | 44 | 24 |
| Gastrointestinal disease, organismal injury and abnormalities, cell death and survival | ADM, AHNAK, ATG7, C3, CFTR, CLDN7, CST5, CTSS, DENND5A, DUSP10, FADS1, FADS2, HAS1, HCAR3, HLA-B, IFNGR1, IL13, IL1B, IL36RN, LBP, MAFF, MS4A4A, NFKBIE, NRIP3, PQLC3, SEL1L3, SLC43A3, SMARCA4, STK33, STMN2, SYT7, TNF, TP63, TUB, WWP1 | 27 | 17 |
| Gene expression, cell cycle, cellular growth and proliferation | ACAD10, BAG1, CBS/CBSL, CCNB2, CDK17, CORO1C, CTR9, DCHS1, ESR1, FGD6, GREB1, HAUS8, HDAC1, HLTF, LTB, NEDD1, NFYB, NR1D1, NR2C1, NR3C1, NUPR1, PLK1, PRMT6, SCUBE2, SMARCE1, SMYD2, SMYD3, SP1, TBX3, TEAD1, TFAP2C, TNFAIP6, TRAFD1, YWHAG, estrogen receptor | 19 | 13 |
| Cellular development, cellular growth and proliferation, cell cycle | CCND1, CDCA2, CDK5, CHD7, CMKLR1, Ctbp, DRAM1, E2F5, ERBB2, GCN1, HCAR1, HEY1, JAG1, LINC-ROR, LIPF, MAFB, MED13L, NOTCH2, NOTCH4, NUAK1, NUMB, OIP5-AS1, PCLAF, PPARGC1A, RFC1, RMST, RUNX3, SLC16A1, SMTN, SOX2, SUV39H1, TMEM119, TMPO, TP53, let-7a-5p | 17 | 12 |
| Gene expression, cell signaling, cellular development | 26s Proteasome, ACACB, ACTA2, AR, ASCL1, ATP6V0D2, BAG1, CD55, CDK5, CDKN1C, CHRM4, CHST1, CKAP4, DAB2, DLL4, FSH, GBP1, H2AFY, HES1, HRK, IER3, LYVE1, Lh, MED12, MTOR, NOTCH1, PGR, PRKD1, PRKD2, SMARCE1, SMTNL1, SSH1, TOP1, TP53I11, YWHAB | 17 | 12 |
| DNA replication, recombination, and repair, cell morphology, cellular function and maintenance | ACTG1, CHPT1, CLOCK, DDX11, DDX5, DTX4, EIF4G2, EP300, FEN1, GATA1, HBB, HNRNPC, HNRNPD, HNRNPU, HUS1, MAX, MYB, OAS3, OTUB1, PARPBP, PCLAF, PCNA, RAD51, RAD9A, RFC1, RHOA, Rnr, SATB1, TMEM241, TP53BP1, TRPV4, USP44, UTP20, XRN2, YBX1 | 15 | 11 |