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. 2019 Sep 12;10(9):705. doi: 10.3390/genes10090705

Figure 3.

Figure 3

RT-PCR analysis of the BACE1 and GAPDH transcripts after treatment with the best working 2’-O-MePS AOs (AO2, AO6, AO12, and AO13) targeting exons 2, 3, and 4 at 100 nM, 50 nM, 25 nM, and 12.5 nM concentrations in HEK293 cells. FL, full-length; UT, untreated; SCR, scrambled sequence; GAPDH was used as a loading control. The gel images were cropped to highlight the BACE1 specific products and the corresponding house-keeping gene control GAPDH. The original images are shown in Figure S4 (Supplementary Information).