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. 2019 Sep 24;10:2281. doi: 10.3389/fimmu.2019.02281

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Copyright © 2019 Guo, Wang, Ye, Shi, Yan, Lin, Huang, Li, Lin, Zhu, Xue and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The mapping network of circRNA-miRNA interactions in SLE. (A) The network map includes the 12 surviving candidates from the 15 significantly altered circRNAs (represented as red nodes) in the analysis for circRNA-miRNA network prediction. The other three differentially expressed circRNAs did not show reliable results in this interaction analysis. The blue nodes around the red node were the predicted miRNAs that interacted with the related circRNAs. (B) Gene ontology (GO) analysis for 12 circRNA-interacting miRNAs and their target genes showing significantly enriched pathways. Red indicates biological process (BP), green indicates molecular function (MF), and blue indicates cellular component (CC). (C) KEGG Pathway analysis for 12 circRNA-interacting miRNAs and their target genes showing significantly enriched signaling pathways. The Y-axis indicates pathway name, and the X-axis indicates the richness factor. The size of the spots represents the number of enriched differential target genes, and change of color from green to red represents the Q-value.