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. 2019 Sep 24;10:2281. doi: 10.3389/fimmu.2019.02281

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Copyright © 2019 Guo, Wang, Ye, Shi, Yan, Lin, Huang, Li, Lin, Zhu, Xue and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Double validation of hsa_circ_0000479 as an SLE diagnosis marker in two additional cohorts. (A) Expression of hsa_circ_0000479 in the validation-phase cohort with 23 SLE patients (including the active group and the stable group) and 21 HCs. (B) Expression of hsa_circ_0000479 in the external validation phase cohort with 64 SLE patients (including the active group and the stable group), 58 HCs, and 50 RA patients. Data are presented as a box plot. The “°” and “*,” respectively, indicate data that are more than 1.5-fold and 3-fold the quartile distance from the upper or lower bounds of the box. (C,D) Receiver operating characteristic (ROC) curves of hsa_circ_0000479 in the validation-phase and external validation-phase cohorts for SLE diagnosis.