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. 2019 Sep 12;20(18):4508. doi: 10.3390/ijms20184508

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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HSP70 (Heat Shock Protein 70) expression regulates NLRP3 (NOD-leucine rich repeat and pyrin containing protein 3) inflammasome activation. Left panel: HSP70 deficiency leads to an overactivation of NLRP3 inflammasome and caspase-1 and to an increased secretion of IL (interleukin)-1β. Middle panel: In physiologic conditions, NLRP3 inflammasome activation and IL-1β secretion are regulated. Right panel: HSP70 overexpression (artificially or through a heat shock) leads to the continued interaction between HSP70 and NLRP3, preventing the interaction between NLRP3 and ASC (Apoptosis associated Speck-like protein containing a CARD domain) and the subsequent caspase-1 activation and IL-1β secretion.