Table 1.

Effects of HSP on the NLRP3 inflammasome.

HSP	Inflammasome Activation	Inflammasome Inhibition	Mechanism
Ext HSP27		+	Competition with acLDL
Int HSP27		+	Unknown
HSP60	+		NF-κB activation/ROS
Intra HSP70		+	Interaction with NLRP3
Ext HSP70	+		NF-κB activation
HSP90	+		Stabilization of the complex with SGT1 and interaction with NLRP3
Gp96	+		NF-κB activation or K+ efflux