| mutp53 | mutant p53 protein |
| GOF | gain-of-function |
| HNSCC | head and neck squamous cell carcinoma |
| DDR | DNA damage response |
| DSBs | DNA double-strand break repair |
| CIN | chromosomal and genomic instability |
| NHEJ | nonhomologous end-joining |
| HR | homologous recombination |
| RFS | recurrence free survival |