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. 2019 Jul 8;3(10):1296–1310. doi: 10.1002/hep4.1397

Figure 2.

Figure 2

APR002 exhibits dose‐proportional IFN‐dependent PD responses with minimal proinflammatory cytokine induction. Following a single oral dose of increasing dosages over a 1,000‐fold range given to C57BL/6 mice, the levels of (A) serum IP‐10, (B) hepatic ISG15 expression, (C) serum IL‐6, and (D) serum TNF‐α are shown as a function of the dose of APR002 or GS‐9620. Cytokine data represent the average pg/mL amount in serum ± SD. Liver ISG15 expression is shown as average fold over vehicle ± SD. Abbreviation: mpk, mg per kg.