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. 2019 Jul 8;3(10):1296–1310. doi: 10.1002/hep4.1397

Figure 7.

Figure 7

Relationship between serum WHV markers, serum activity of liver enzymes, peripheral ISG expression, and anti‐WHV antibody elicitation in woodchucks with undetectable or suppressed WHV replication induced by ETV/APR002 combination therapy. Log10 changes in serum WHV DNA and WHsAg, fold changes in blood OAS1 and ISG15 expression, and percentage changes in ALT and SDH levels and anti‐WHs antibody titers relative to pretreatment (T0) in woodchucks (A) F6008, (B) M6015, (C) M6002, and (D) M6021 during ETV/APR002 combination therapy (Groups 3 and 4).