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. 2019 Oct 1;17:328. doi: 10.1186/s12967-019-2079-9

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — SORAMIC trial design. Indicated in red are the time points chosen for discovery of the variants. SNV, single nucleotide variant; InDel, insertion and deletion; R, randomization; TX, therapy; RFA, radiofrequency ablation; ⁹⁰Y-RE, ⁹⁰Y-radioembolization