Table 1.

Patient’s and tumor characteristics according to ctDNA status

Clinico-pathologic features	Pre-op ctDNA-negative	Pre-op ctDNA-positive	P value	Post-op ctDNA-negative	Post-op ctDNA-positive	P value
	N = 14 (%)	N = 23 (%)		N = 22 (%)	N = 13 (%)
Median age (years)	66	65		66	65
Age range	48–79	48–81		47–79	48–77
Sex
Male	10 (71)	13 (57)	0.49	12 (55)	9 (69)	0.49
Female	4 (29)	10 (43)		10 (45)	4 (31)
CA-19-9 < 36 U/ml	6 (43)	4 (17)
CA-19-9 > 36 U/ml	8 (57)	19 (83)	0.13
Tumor location
Pancreas head	10 (71)	20 (87)	0.64	16 (73)	12 (92)	0.37
Pancreas body	1 (7)	3 (13)		3 (14)	1 (8)
Pancreas tail	2 (15)	0 (0)		2 (9)	0 (0)
Not reported	1 (7)	0 (0)		1 (4)	0 (0)
T stage
T1	0 (0)	1 (4)	0.43	0 (0)	0 (0)	>0.99
T2	2 (15)	1 (4)		2 (9)	1 (8)
T3	12 (85)	21 (91)		20 (91)	12 (92)
N status
N0	4 (29)	2 (9)	0.17	5 (23)	1 (8)	0.37
N1	10 (71)	21 (91)		17 (77)	12 (92)
R status
R0	5 (36)	11 (48)	0.12	12 (55)	5 (38)	0.15
R1	9 (64)	7 (30)		10 (45)	6 (46)
Rx	0 (0)	3 (13)		0 (0)	2 (16)
Lymphvascular invasion
Absent	4 (29)	6 (26)	0.53	5 (23)	3 (23)	0.53
Present	10 (71)	15 (65)		16 (73)	8 (61)
Not reported	0 (0)	2 (9)		1 (4)	2 (16)
Perineural invasion
Absent	2 (15)	6 (26)	0.32	5 (23)	2 (16)	0.83
Present	12 (85)	15 (65)		16 (73)	10 (76)
Not reported	0 (0)	2 (9)		1 (4)	1 (8)
Adjuvant chemotherapy
Yes	13 (93)	16 (70)		21 (96)	7 (54)
No	1 (7)	7 (30)		1 (4)	6 (46)