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. 2019 Aug 14;9(22):6354–6368. doi: 10.7150/thno.34008

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The iMSC showed poor longevity and transdifferentiation potential in nude rat ED model. (A) The transcripts for human smooth muscle (SMA) and endothelial markers (vWF and eNOS) were detected in 3, 7, and 15 days after intracavernousal injection in penis of CNI ED nude rats. The longevity of iMSC and adMSC in penis were determined by the transcripts of human GAPDH. iMSC RNA, adMSC RNA, and rat universal mRNA were also measured. Rat GAPDH was adopted as control. (B-C) There was no evidence that iMSC transdifferentiated into smooth muscle cell or endothelial cell for no PKH-67 labelled iMSC colocalized with SMA or vWF expression. The iMSC were also disappeared 7 days after intracavernousal injection in penis of CNI ED nude rats.