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. 2019 Sep 17;9(22):6646–6664. doi: 10.7150/thno.33741

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HUMSCs stimulate macrophages to synthesize MMP-9 and release HA to trigger alveolar epithelial expression of TLR-4 in the coculture system. Western blot images represent the content of MMP-9 in alveolar macrophages in the coculture of pulmonary macrophages, fibroblasts and HUMSCs. The quantitative results indicate that HUMSCs can enhance MMP-9 synthesis in macrophages after BLM treatment (A). The quantity of HA released into the media by HUMSCs is cell amount-dependent (B). Western blot images from the coculture of alveolar cells and HUMSCs showed that HUMSCs resulted in an increase in TLR-4 expression in the alveolar cells, irrespective of BLM (C). n=4. ✱, p < 0.05.