Figure 1.

ART synergized with NVB to inhibit breast cancer cell line proliferation. (A) An 8 × 8 dose matrix was generated for ART × NVB. The effects of combined ART/NVB treatment on MDA-MB-231, MCF-7, and MCF-10A cell proliferation. (B) Synergy was also described by preparing isobolograms to compare the doses needed to reach 50% inhibition along an equal-effect contour to those along a predicted contour, based on a model of dose additivity. A CI of 1.0 (dotted line) reflects additive effects, whereas values greater than or less than 1.0 indicate antagonism or synergy, respectively. All dosing combinations show synergy as determined by the Chou-Talalay method.