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. 2019 Aug 21;9(22):6568–6586. doi: 10.7150/thno.35353

Figure 7.

Figure 7

In vivo antitumor efficacy of orally administered PreCDDP/YC in mice bearing A549 xenografts. (A) Changes in the tumor volume during treatment with either saline or free CDDP administered by oral gavage. (B) Tumor weight of A549 xenografts at day 24 after treatment. (C) Changes in the relative tumor volume of A549 xenografts during treatment with orally administered free CDDP or PreCDDP/YC. (D-E) The tumor volume (D) and relative tumor volume (E) of A549 xenografts during treatment with orally administered PreCDDP/YC or intravenously injected CDDP (i.v. CDDP). Mice in the control group were treated with saline. To calculate the relative tumor volume, measured tumor volumes at varied time points were normalized to those at day 0. (F-G) Tumor weight (F) and H&E-stained sections (G) of A549 xenografts isolated from mice after different treatments. Scale bars, 200 μm. Data are mean ± SD (A-C, n = 6; D-F, n = 8); *p < 0.05; ns, no significance.