Table 1.
Functionalities and mechanisms of example lncRNAs and miRNAs as biomarkers or therapeutic cancer targets.
| Name | Type | Functionality | Mechanism | References |
|---|---|---|---|---|
| AF075069 | lncRNA | Post-transcriptional regulation | mRNA turnover | (31) |
| Bace1-AS | lncRNA | Post-transcriptional regulation | mRNA turnover | (32) |
| BC009800 | lncRNA | Post-transcriptional regulation | mRNA turnover | (31) |
| BC058830 | lncRNA | Post-transcriptional regulation | mRNA turnover | (31) |
| CCAT1 | lncRNA | Post-transcriptional regulation | miRNA sponge | (33) |
| Falcor | lncRNA | Transcriptional regulation | Transcribed within distal enhancer | (34) |
| FER1L4 | lncRNA | Post-transcriptional regulation | miRNA sponge | (35) |
| HOTAIR | lncRNA | Transcriptional regulation | Interaction with histone methyltransferase | (36) |
| H19 | lncRNA | Post-transcriptional regulation | miRNA reservoir | (37) |
| H19 | lncRNA | Post-transcriptional regulation | miRNA sponge | (38) |
| LincRNA-p21 | lncRNA | Post-transcriptional regulation | mRNA translation | (39) |
| MALAT1 | lncRNA | Post-transcriptional regulation | mRNA splicing | (40) |
| NEAT1 | lncRNA | Post-transcriptional regulation | miRNA sponge | (41) |
| PTENpg1 | lncRNA | Transcriptional regulation | Interaction with DNA methyltransferase | (42) |
| SPRY4-IT1 | lncRNA | Post-transcriptional regulation | miRNA sponge | (43) |
| SRG1 | lncRNA | Transcriptional regulation | Transcribed within adjacent gene promoter | (44) |
| Uchl1-AS | lncRNA | Post-transcriptional regulation | mRNA translation | (45) |
| XIST | lncRNA | Transcriptional regulation | Interaction with histone methyltransferase | (46) |
| XIST | lncRNA | Post-transcriptional regulation | miRNA sponge | (47) |
| miR-193b | miRNA | Post-transcriptional regulation | Targeting gene | (48) |
| miR-200c-3p | miRNA | Post-transcriptional regulation | Targeting gene | (49) |
| miR-21 | miRNA | Post-transcriptional regulation | Halt protein translation | (50) |
| miR-221/222 | miRNA | Transcriptional regulation | Targeting lncRNA | (51) |
| miR-31 | miRNA | Post-transcriptional regulation | Targeting gene | (52) |
| miR-372 | miRNA | Post-transcriptional regulation | Targeting gene | (35) |
| miR-4286 | miRNA | Post-transcriptional regulation | Targeting gene | (53) |
| miR-513b | miRNA | Post-transcriptional regulation | Targeting gene | (54) |
| miR-603 | miRNA | Post-transcriptional regulation | Halt protein translation | (55) |
| miR-663a | miRNA | Transcriptional regulation | Targeting lncRNA | (56) |
| miR-92b | miRNA | Post-transcriptional regulation | Halt protein translation | (57) |