Table 2.
Example clinical trials involving miRNAs as cancer biomarkers.
| Name | Panel size | Study type | Study size | Clinical use | Cancer type | References |
|---|---|---|---|---|---|---|
| 7-miR panel | 7 | Multicenter, retrospective, longitudinal study | 257 patients for discovery, 352 and 139 patient from two cohorts for validation | Early detection | Hepatocellular carcinoma | (106) |
| 6-miR panel | 6 | MicroRNA expression analysis | 40 patients for discovery, 138 for validation | Risk of disease progression | Stage II colon cancer | (107) |
| MiROvaR | 35 | Cohort study | 179 patients for discovery, 263 and 452 patients from two cohorts for validation | Early relapse or progression | Epithelial ovarian cancer | (108) |
| 6-miR panel | 6 | Phase II clinical trial | 2 cell lines for discovery, 97 patients for validation | Early relapse or progression | Prostate cancer | (110) |