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. 2019 Sep 24;9:948. doi: 10.3389/fonc.2019.00948

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Copyright © 2019 Zhan, Li and Ge.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cancer-related pathways regulated by asporin in different types of cancer. Asporin not only promotes cancer cell proliferation, migration, and invasion by binding with CD44 and Smad 2/3 as well as promoting the phosphorylation of EGFR, but also inhibits cancer cell migration and invasion by binding with TGF-β in the extracellular matrix. Upregulated and downregulated proteins are shown in solid red and green arrows, respectively. Original elements used in this diagram are from Servier Medical Art (http://smart.servier.com/).