Table 2.
List of 21 miRNAs linked to both AD and cancer according to HMDDa.
| miRNA | ALZCAN (Gen)b | miRNA Targets |
|---|---|---|
| hsa-miR-16-5p | 29 (1,557) | KRAS, CDKN2A, ABCC4, HTRA1, CIB1, ASCC1, WT1, RPSA, TKTL1, APP, PTGS2, GSK3B, HIGD1A, ADRA2B, IGF1R, BRCA1, EGFR, BSG, MTOR, SQSTM1, AGER, PRKAA1, ALDH2, SNCG, TARBP2, HSPA9, PRNP, TP53, HSP90AA1 |
| hsa-miR-34a-5p | 20 (735) | CDKN2A, RCAN1, WNT1, CAPN1, BAG3, HMGB1, PPARA, XRCC1, DLL1, SIRT1, AKR7A2, IGF1R, PPP3R1, BRCA1, PIK3CG, TNF, CTNNB1, BECN1, NOTCH1, TP53 |
| hsa-miR-26b-5p | 25 (1,874) | CAPN9, TSPAN12, HTRA1, CIB1, STUB1, NRDC, FOLH1, PARK7, BAG3, INSR, HMGB1, LRP1B, PTGS2, GSK3B, IGF1R, PPP3R1, BRCA1, PIK3CG, PRKAA1, TLR4, PRKN, ADAM17, ABCG2, ATP2A2, TARBP2 |
| hsa-miR-15a-5p | 16 (717) | CDKN2B, ASCC1,WT1, TKTL1, APP, ATF2, GSK3B, HIGD1A, ADRA2B, BRCA1, BSG, UCP2, PRKAA1, SNCG, TARBP2, TP53 |
| hsa-miR-181a-5p | 14 (553) | KRAS, HDAC6, GSKIP, PTGS2, SIRT1, BRCA1, PEBP1, UCHL1, PRKN, ADAM17, ABCG2, CTNNB1, IL1A, NOTCH1 |
| hsa-miR-155-5p | 16 (904) | KRAS, CDKN2A, ABCC4, HTRA1, PSEN1, ADAM10, SIRT1, GSK3B, AKR7A2, EGFR, SH3PXD2A, PEBP1, DHCR24, AKAP10, CTNNB1, IL6 |
| hsa-miR-125b-5p | 12 (431) | CDKN2A, ABCC4, NRDC, S100A8, IGF1R, EGFR, AKAP2, TNF, MMP2, NME2, BACE2, TP53 |
| hsa-miR-9-5p | 11 (350) | ESR1, PPARA, SIRT1, GSK3B, LMNA, PRKAA1, LRP1, MMP2, BECN1, IL6, NOTCH1 |
| hsa-miR-195-5p | 12 (639) | INSR, ASCC1, TKTL1, APP, GSK3B, HIGD1A, ADRA2B, BSG, AGER, PRKAA1, SNCG, TARBP2 |
| hsa-miR-146a-5p | 8 (102) | PTGS2, BRCA1, EGFR, SQSTM1, TLR4, IL6, NOTCH1, SOS1 |
| hsa-miR-17-5p | 15 (1,181) | ESR2, APEX1, HMGB1, RPSA,APP, AKR7A2, PPP3R1, SQSTM1, TNF, MMP2, NBR1, HSPB2, PRNP, TP53, HSP90AA1 |
| hsa-miR-27a-3p | 10 (429) | KRAS, APEX1, PPARG, GSK3B, EGFR, PIK3CG, SNCG, NME2, TP53, SOS1 |
| hsa-miR-15b-5p | 12 (760) | INSR, ASCC1, TKTL1, APP, GSK3B, HIGD1A, ADRA2B, BSG, PRKAA1, SNCG, ATP2A2, TARBP2 |
| hsa-miR-21-5p | 11 (611) | STUB1, HMGB1, PPARA, ATF2, ABCB1, IGF1R, BRCA1, EGFR, TLR4, MMP2, IL1B |
| hsa-miR-142-3p | 9 (389) | ESR1, HMGB1, XRCC1, PIK3CG, ABCG2, CTNNB1, IL1A, ATP2A2, IL6 |
| hsa-miR-26a-5p | 9 (457) | ESR1, PTGS2, GSK3B, BRCA1, PIK3CG, PRKAA1, ADAM17, IL6, DNMT3B |
| hsa-miR-100-5p | 7 (251) | ESR1, APEX1, HMGB1, IGF1R, MTOR, BECN1, ATP2A2 |
| hsa-let-7b-5p | 13 (1,215) | NRDC, RCAN1, SIGMAR1, HMGB1, RPSA, PTGS2, GSK3A, PPARGC1A, IGF1R, SH3PXD2A, TLR4, ATP2A2, HSP90AA1 |
| hsa-miR-7-5p | 9 (578) | SIGMAR1, IDE, AKR7A2, IGF1R, EGFR, SQSTM1, PIK3CG, TLR4, SNCA |
| hsa-miR-375 | 8 (477) | CDKN2B, IGF1R, PEBP1, CTNNB1, IFI6, TP53, HSP90AA1, DNMT3B |
| hsa-miR-181c-5p | 6 (291) | KRAS, GSKIP, SIRT1, PEBP1, ADAM17, IL1A |
aHMDD, Human MicroRNA Disease Database (HMDD v3.0); bnumber of genes of ALZCAN gene set (total number of genes in the genome according to ToppGene). For more details, see Supplementary Table S6.