Figure 1.

Functions of PTEN in stromal fibroblasts. Stromal PTEN acts to mediate (A) an oncogenic secretome via the PTEN/miR-320/ETS2 axis, (B) cross talk with neighboring epithelium, (C) response to radiotherapy, and (D) extracellular matrix (ECM) remodeling. EGF, Epidermal growth factor; EGFR, EGF receptor. (Panel A is based on data in Bronisz et al. 2012; panel B is based on data in Sizemore et al. 2017; panel C is based on data in Sizemore et al. 2018; and panel D is based on data in Trimboli et al. 2009, Jones et al. 2019, and Pitarresi et al. 2018.)