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. 2019 Aug 14;3(10):1356–1372. doi: 10.1002/hep4.1413

Figure 5.

Figure 5

OLMALINC regulates SCD gene expression in cis by forming DNA–DNA looping interactions. (A) Promoter Capture Hi‐C data in HepG2 cells demonstrate DNA–DNA looping interactions between the OLMALINC enhancer/promoter and the SCD promoter/enhancer regions. (B) Endogenous OLMALINC overexpression using aCRISPR‐dCa9 gene editing increases expression of SCD. (C) Overexpression of the spliced OLMALINC stable transcript (exons 1‐3) for 48 hours does not affect SCD gene expression. Expression data are normalized to a GFP negative control. Values are mean ± SD (n = 3). **P < 0.01, ***P < 0.001 (unpaired Student t test was used for two groups). Abbreviations: GFP, green fluorescent protein; ns, not significant.