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. 2019 Oct;29(10):1648–1658. doi: 10.1101/gr.244251.118

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© 2019 Feigin et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — TWAR-associated genes are enriched for functions in cranial nerve and brain development. (A) Transgenic mouse fetus (e11.5) showing LacZ reporter gene expression in the trigeminal ganglion, driven by hs1433, an enhancer tiled by TARs and WARs (Gray et al. 2004; Visel et al. 2007). (B) In situ hybridization showing the mRNA localization of Mecom in the trigeminal ganglion at e10.5. Mecom is the nearest coding gene to enhancer hs1433. (From Gray et al. 2004. Reprinted with permission from the American Association for the Advancement of Science [AAAS].) (C) Unscaled Venn diagram showing overlap between TWAR-associated genes with roles in cranial nerve phenotypes, TGF beta/BMP signaling and responsive genes, transcription factors, and genes with roles in mouse facial morphology. (D) Unscaled Venn diagram showing overlap between TWAR-associated genes expressed in the basal ganglion with genes related to axon guidance and cell migration.