Table 1:
Summary of oHSVs
| Virus | Deletion/Mutation | Foreign gene/promoter insertion | Reference |
|---|---|---|---|
| C130 | Deletion in both copies of γ134.5 gene | Expresses the HCMV TRS1 gene product | (43) |
| C134 | Deletion in both copies of γ134.5 gene | IRS1 gene under control of an HCMV immediate early promoter | (43, 44, 60) |
| dlsptk | Thymidine-kinase deficient | None | (7) |
| G207 | Deletion in both copies of γ134.5 gene and disabling lacZ insertion in UL39 | None | (6, 8, 16, 17, 24, 30, 37, 51, 89) |
| G47∆ | Deletion of the γ134.5 and α47 genes and a disabling lacZ insertion within ICP6 | Murine angiostatin | (14, 20, 75) |
| G47∆-IL12 | Deletion of the γ134.5 and α47 genes and a disabling lacZ insertion within ICP6 | Murine IL-12 gene insert | (72, 73, 85) |
| HSV1716 | Deletion in both copies of γ134.5 gene | None | (9–12, 23) |
| M002 | Deletion in both copies of γ134.5 gene | Murine IL-12 gene insert | (30, 67, 68, 70) |
| M032 | Deletion in both copies of γ134.5 gene | Human IL-12 gene insert | (71) |
| NG34 | Deletion in ICP6 and ICP34.5 genes | Human GADD34 gene transcriptionally controlled by the Nestin promoter | (41) |
| R-115 | None | Murine IL-12; CMV promoter | (36) |
| R5141 | Deletion of polylysine tract in gB | Insertion of IL-13 between amino acids 24 and 25 of gD | (38) |
| R5181 | Deletion of polylysine tract in gB | Insertion of urokinase plasminogen activator between amino acids 24 and 25 of gD | (39) |
| RAMBO | Deletion in both copies of γ134.5 gene and in-frame gene-disrupting insertion of GFP within ICP6 gene | Vasculostatin (Vstat120) under control of the HSV IE 4/5 promoter | (74) |
| rHSVQ1 | Deletion in UL39 and γ134.5 genes | None | (40, 45) |
| rQNestin34.5v.2 | Deletion in γ134.5 gene and UL39 | ICP-34.5 under control of synthetic nestin promoter | (40, 45) |
| talimogene laherparepvec (T-Vec) | Deletions of the ICP34.5 and ICP47 genes | Granulocyte-macrophage colony-stimulating factor, CMV promoter | (13, 86) |